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Case Report
 
Benign electrocardiographic changes and diaphragmatic contractions while using the NanoKnife: A case report
Mariese Cooper1, Stevan Mihailovic2, Zoka Milan3
1MBBS, BMedSci (Hons), FRCA, ST7, Anaesthetic Department, King's College Hospital, London, UK.
2MD, Consultant Anaesthetist, Specialist of Anesthesiology, Reanimatology and intensive therapy, Opsta Bolnica Pancevo, Pancevo, Serbia.
3MD, PhD, FRCA, FCIM, Consultant Anaesthetist, Honorary Senior Lecturer, Visiting Professor, King's, College Hospital, London, UK.

Article ID: 100005A05MC2016
doi:10.5348/A05-2016-5-CR-1

Address correspondence to:
Mariese Cooper
King's College Hospital
London, UK, SE5 9RS

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How to cite this article
Cooper M, Mihailovic S, Milan Z. Benign electrocardiographic changes and diaphragmatic contractions while using the NanoKnife: A case report. Edorium J Anesth 2016;2:1–5.


Abstract
Introduction: The NanoKnife is a relatively new non-thermal tumor ablation tool. It is based on the creation of nanoscale defects in the cell membrane lasting long enough to induce cell death. Although considered a minimally invasive technique, side effects are still possible.
Case Report: We describe a patient who had benign electrocardiography (ECG) changes in the form of tall T-waves with no apparent hemodynamic consequence. The patient also had regular right diaphragmatic contractions that slightly affected ventilatory curves during positive pressure ventilation, without clinical implications.
Conclusion: Irreversible electroporation represents a new method for tumor ablation. It appears to be safe and promising, especially with the application of advanced ECG-synchronizing devices. This example shows that we should be careful when implementing new techniques and that we should add our experiences to a global database to enhance the learning process.

Keywords: Benign arrhythmia, Diaphragmatic contraction, General anesthetic, NanoKnife, Neuromuscular blockade


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Author Contributions
Mariese Cooper – Acquisition of data, Drafting the article, Final approval of the version to be published
Stevan Mihailovic – Analysis and interpretation of data, Revising it critically for important intellectual content, Final approval of the version to be published
Zoka Milan – Substantial contributions to conception and design, Revising it critically for important intellectual content, Final approval of the version to be published
Guarantor of submission
The corresponding author is the guarantor of submission.
Source of support
None
Conflict of interest
Authors declare no conflict of interest.
Copyright
© 2016 Mariese Cooper et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.